Similarity ensemble approach (SEA)
The Similarity ensemble approach relates proteins based on the set-wise
chemical similarity among their ligands. It can be used to rapidly search
large compound databases and to build cross-target similarity maps.
How to use SEA
You can try SEA yourself via the online
SEA search tool
SEA is provided by the
Shoichet Laboratory in the
Department of Pharmaceutical Chemistry at the
University of California, San Francisco (UCSF).
To determine whether SEA's predictions for your compounds are already
known, we recommend you visit the extensive
at the NIMH Psychoactive Drug Screening Program.
How to cite SEA
If you use SEA results in your publications, please cite the following:
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007).
Pubmed | DOI | PDF
The following SEA results were referenced in this paper: